Integrated genomic characterization of pancreatic ductal adenocarcinoma
We performed integrated genomic, transcriptomic, and proteomic profiling of 150 pancreatic
ductal adenocarcinoma (PDAC) specimens, including samples with characteristic low
neoplastic cellularity. Deep whole-exome sequencing revealed recurrent somatic mutations
in KRAS, TP53, CDKN2A, SMAD4, RNF43, ARID1A, TGFβR2, GNAS, RREB1, and PBRM1.
KRAS wild-type tumors harbored alterations in other oncogenic drivers, including GNAS,
BRAF, CTNNB1, and additional RAS pathway genes. A subset of tumors harbored multiple …
ductal adenocarcinoma (PDAC) specimens, including samples with characteristic low
neoplastic cellularity. Deep whole-exome sequencing revealed recurrent somatic mutations
in KRAS, TP53, CDKN2A, SMAD4, RNF43, ARID1A, TGFβR2, GNAS, RREB1, and PBRM1.
KRAS wild-type tumors harbored alterations in other oncogenic drivers, including GNAS,
BRAF, CTNNB1, and additional RAS pathway genes. A subset of tumors harbored multiple …
Integrated genomic characterization of pancreatic ductal adenocarcinoma
Cancer Genome Atlas Research Network - Cancer cell, 2017 - pmc.ncbi.nlm.nih.gov
We performed integrated genomic, transcriptomic and proteomic profiling of 150 pancreatic
ductal adenocarcinoma (PDAC) specimens, including samples with characteristic low
neoplastic cellularity. Deep whole-exome sequencing revealed recurrent somatic mutations
in KRAS, TP53, CDKN2A, SMAD4, RNF43, ARID1A, TGFβR2, GNAS, RREB1 and PBRM1.
KRAS wild-type tumors harbored alterations in other oncogenic drivers, including GNAS,
BRAF, CTNNB1 and additional RAS pathway genes. A subset of tumors harbored multiple …
ductal adenocarcinoma (PDAC) specimens, including samples with characteristic low
neoplastic cellularity. Deep whole-exome sequencing revealed recurrent somatic mutations
in KRAS, TP53, CDKN2A, SMAD4, RNF43, ARID1A, TGFβR2, GNAS, RREB1 and PBRM1.
KRAS wild-type tumors harbored alterations in other oncogenic drivers, including GNAS,
BRAF, CTNNB1 and additional RAS pathway genes. A subset of tumors harbored multiple …
