A characteristic symptom of neuropathic pain is mechanical allodynia. In animal models of
neuropathic pain, mechanical allodynia is often assessed using von Frey filaments.
Although the forces applied with these filaments are highly reproducible, there are various
disadvantages of using this method. Testing paradigms and definitions of withdrawal
threshold are not standardised. Moreover, measurements may be influenced by various
conditions, such as ambient temperature, humidity, weight bearing of the limb and stress …