To the Editor: The Sézary syndrome is a leukemic, cutaneous, epidermotropic T-cell lymphoma. Pruritus, insomnia, and depression impair the quality of life and can lead to suicide.¹ Substance P is a key mediator of pruritus.² An increase in the expression of its receptor, neurokinin-1, has been reported on keratinocytes in pruritic skin diseases.³ Aprepitant is an oral neurokinin-1–receptor antagonist.⁴ It is widely used as an antiemetic agent in chemotherapy-induced nausea and vomiting.⁵ However, its action suggests a potential reduction in substance P–induced pruritus, even though pruritus is considered a rare side effect of this drug.

We report on three patients . . .