Chemokines and chemokine receptors: biology and clinical relevance in inflammation and AIDS
M Locati, MD, PM Murphy, MD - Annual review of medicine, 1999 - annualreviews.org
Chemokines constitute a large family of chemotactic cytokines that act at G protein-coupled
receptors to regulate diverse biological processes, including leukocyte trafficking,
angiogenesis, hematopoiesis, and organogenesis. They are believed to be both beneficial
in host defense against infectious agents and harmful in diseases marked by pathologic
inflammation; however, actual clinical roles in these areas have not yet been established.
Recently, unexpected ways have been discovered in which medically important pathogens …
receptors to regulate diverse biological processes, including leukocyte trafficking,
angiogenesis, hematopoiesis, and organogenesis. They are believed to be both beneficial
in host defense against infectious agents and harmful in diseases marked by pathologic
inflammation; however, actual clinical roles in these areas have not yet been established.
Recently, unexpected ways have been discovered in which medically important pathogens …