Oxidized low density lipoprotein inhibits macrophage apoptosis by blocking ceramide generation, thereby maintaining protein kinase B activation and Bcl-XL levels
RS Hundal, A Gómez-Muñoz, JY Kong, BS Salh… - Journal of Biological …, 2003 - jbc.org
Macrophages play a central role in the development and progression of atherosclerotic
lesions. It is well known that oxidized low density lipoprotein (ox-LDL) promotes the
recruitment of monocytes (which differentiate to macrophages) into the intima. We reported
recently that ox-LDL blocks apoptosis in bone marrow-derived macrophages deprived of
macrophage colony-stimulating factor (M-CSF) by a mechanism involving protein kinase B
(PKB)(Hundal, R., Salh, B., Schrader, J., Gómez-Muñoz, A., Duronio, V., and Steinbrecher …
lesions. It is well known that oxidized low density lipoprotein (ox-LDL) promotes the
recruitment of monocytes (which differentiate to macrophages) into the intima. We reported
recently that ox-LDL blocks apoptosis in bone marrow-derived macrophages deprived of
macrophage colony-stimulating factor (M-CSF) by a mechanism involving protein kinase B
(PKB)(Hundal, R., Salh, B., Schrader, J., Gómez-Muñoz, A., Duronio, V., and Steinbrecher …