Modulation of atherogenesis by chemokines
WA Boisvert - Trends in Cardiovascular Medicine, 2004 - Elsevier
Migration of leukocytes into the vasculature—which involves the concerted effort of many
molecules, including chemokines—is a requisite step for atherogenesis. The three
chemokines that have been implicated most strongly in atherogenesis are monocyte
chemoattractant protein 1 (MCP-1), interleukin 8 (IL-8)/growth-regulated oncogene α (Gro-
α), and fractalkine. Although all three chemokines appear to impact atherogenesis by
attenuating monocyte/macrophage accumulation in the lesion, the precise mechanism of …
molecules, including chemokines—is a requisite step for atherogenesis. The three
chemokines that have been implicated most strongly in atherogenesis are monocyte
chemoattractant protein 1 (MCP-1), interleukin 8 (IL-8)/growth-regulated oncogene α (Gro-
α), and fractalkine. Although all three chemokines appear to impact atherogenesis by
attenuating monocyte/macrophage accumulation in the lesion, the precise mechanism of …