Inositol phosphates and cell signalling
MJ Berridge, RF Irvine - Nature, 1989 - nature.com
MJ Berridge, RF Irvine
Nature, 1989•nature.comAbstract Inositol 1, 4, 5-trisphosphate is a second messenger which regulates intracellular
calcium both by mobilizing calcium from internal stores and, perhaps indirectly, by
stimulating calcium entry. In these actions it may function with its phosphorylated metabolite,
inositol 1, 3, 4, 5-tetrakisphosphate. The subtlety of calcium regulation by inositol
phosphates is emphasized by recent studies that have revealed oscillations in calcium
concentration which are perhaps part of a frequency-encoded second-messenger system.
calcium both by mobilizing calcium from internal stores and, perhaps indirectly, by
stimulating calcium entry. In these actions it may function with its phosphorylated metabolite,
inositol 1, 3, 4, 5-tetrakisphosphate. The subtlety of calcium regulation by inositol
phosphates is emphasized by recent studies that have revealed oscillations in calcium
concentration which are perhaps part of a frequency-encoded second-messenger system.
Abstract
Inositol 1,4,5-trisphosphate is a second messenger which regulates intracellular calcium both by mobilizing calcium from internal stores and, perhaps indirectly, by stimulating calcium entry. In these actions it may function with its phosphorylated metabolite, inositol 1,3,4,5-tetrakisphosphate. The subtlety of calcium regulation by inositol phosphates is emphasized by recent studies that have revealed oscillations in calcium concentration which are perhaps part of a frequency-encoded second-messenger system.
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