Novel human serum protein from fibroblast plasma membrane
E Ruoslahti, A Vaheri - Nature, 1974 - nature.com
E Ruoslahti, A Vaheri
Nature, 1974•nature.comCELL surface components play a major role in the control of normal cell interactions and in
the altered growth control and antigenic properties of malignant cells1. To characterise
tissue-specific cell surface proteins we undertook an immunochemical study of the material
released from cells by mild proteolytic treatment. Our studies have disclosed a fibroblast-
specific cell surface and serum antigen in chicken2. The amount of this antigen is greatly
reduced in chicken fibroblasts transformed by Rous sarcoma virus.
the altered growth control and antigenic properties of malignant cells1. To characterise
tissue-specific cell surface proteins we undertook an immunochemical study of the material
released from cells by mild proteolytic treatment. Our studies have disclosed a fibroblast-
specific cell surface and serum antigen in chicken2. The amount of this antigen is greatly
reduced in chicken fibroblasts transformed by Rous sarcoma virus.
Abstract
CELL surface components play a major role in the control of normal cell interactions and in the altered growth control and antigenic properties of malignant cells1. To characterise tissue-specific cell surface proteins we undertook an immunochemical study of the material released from cells by mild proteolytic treatment. Our studies have disclosed a fibroblast-specific cell surface and serum antigen in chicken2. The amount of this antigen is greatly reduced in chicken fibroblasts transformed by Rous sarcoma virus.
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