Adrenomedullin selectively inhibits angiotensin II-induced aldosterone secretion in humans
MC Petrie, C Hillier, JJ Morton… - Journal of …, 2000 - journals.lww.com
MC Petrie, C Hillier, JJ Morton, JJV McMurray
Journal of hypertension, 2000•journals.lww.comObjective Adrenomedullin inhibits angiotensin II stimulated aldosterone production in vitro
and in vivo in experimental animals. The aim of this study was to investigate the effect of
adrenomedullin on angiotensin II and adrenocorticotrophic hormone-stimulated aldosterone
production in vivo in healthy humans. Design and Methods Seven volunteers were studied
in a quiet, temperature-controlled laboratory. After 35 min of rest, an infusion of placebo or
adrenomedullin (3 pmol/kg per min) was given over 60 min; 15 min after starting this first …
and in vivo in experimental animals. The aim of this study was to investigate the effect of
adrenomedullin on angiotensin II and adrenocorticotrophic hormone-stimulated aldosterone
production in vivo in healthy humans. Design and Methods Seven volunteers were studied
in a quiet, temperature-controlled laboratory. After 35 min of rest, an infusion of placebo or
adrenomedullin (3 pmol/kg per min) was given over 60 min; 15 min after starting this first …
Objective Adrenomedullin inhibits angiotensin II stimulated aldosterone production in vitro and in vivo in experimental animals. The aim of this study was to investigate the effect of adrenomedullin on angiotensin II and adrenocorticotrophic hormone-stimulated aldosterone production in vivo in healthy humans.
Design and Methods Seven volunteers were studied in a quiet, temperature-controlled laboratory. After 35 min of rest, an infusion of placebo or adrenomedullin (3 pmol/kg per min) was given over 60 min; 15 min after starting this first infusion, a second infusion of angiotensin II (0.96 fmol/kg per min) or adrenocorticotrophic hormone (0.1 mIU/kg per min) was co-infused and continued for 45 min.
Results Adrenomedullin significantly inhibited angiotensin II stimulated aldosterone production: the increment in aldosterone on the placebo day was 691 pmol/l compared with 552 pmol/l on the adrenomedullin day (P< 0.004). Adrenomedullin did not inhibit adrenocorticotrophic hormone-stimulated aldosterone or cortisol release.
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