Rescue of the mature B cell compartment in BAFF-deficient mice by treatment with recombinant Fc-BAFF
LK Swee, A Tardivel, P Schneider, A Rolink - Immunology letters, 2010 - Elsevier
BAFF deficiency in mice impairs B cell development beyond the transitional stage 1 in the
spleen and thus severely reduces the size of follicular and marginal zone B cell
compartments. Moreover, humoral immune responses in these mice are dramatically
impaired. We now addressed the question whether the decrease in mature B cell numbers
and the reduced humoral immune responses in BAFF-deficient mice could be overcome by
the injection of recombinant BAFF. We therefore engineered a recombinant protein …
spleen and thus severely reduces the size of follicular and marginal zone B cell
compartments. Moreover, humoral immune responses in these mice are dramatically
impaired. We now addressed the question whether the decrease in mature B cell numbers
and the reduced humoral immune responses in BAFF-deficient mice could be overcome by
the injection of recombinant BAFF. We therefore engineered a recombinant protein …