The role of IL-11 in immunity and cancer
Abstract Interleukin-11 (IL-11) is a member of the glycoprotein-130 (GP-130) cytokines that
utilizes the GP-130 signaling pathway shared by other cytokines of the same family.
Traditionally regarded as an anti-inflammatory cytokine, IL-11 also demonstrates its role as a
proinflammatory cytokine, suggesting its complex role in immune response. In recent years,
IL-11 has an emerging role in various inflammation-associated cancers. In this review, we
aim to discuss IL-11 signaling pathway, to explore the role of IL-11 in immunity and various …
utilizes the GP-130 signaling pathway shared by other cytokines of the same family.
Traditionally regarded as an anti-inflammatory cytokine, IL-11 also demonstrates its role as a
proinflammatory cytokine, suggesting its complex role in immune response. In recent years,
IL-11 has an emerging role in various inflammation-associated cancers. In this review, we
aim to discuss IL-11 signaling pathway, to explore the role of IL-11 in immunity and various …
Abstract
Interleukin-11 (IL-11) is a member of the glycoprotein-130 (GP-130) cytokines that utilizes the GP-130 signaling pathway shared by other cytokines of the same family. Traditionally regarded as an anti-inflammatory cytokine, IL-11 also demonstrates its role as a proinflammatory cytokine, suggesting its complex role in immune response. In recent years, IL-11 has an emerging role in various inflammation-associated cancers. In this review, we aim to discuss IL-11 signaling pathway, to explore the role of IL-11 in immunity and various cancers, and to provide a therapeutic perspective of strategies utilized to interfere IL-11 signaling in cancer cells.
Elsevier