[HTML][HTML] Hepatic secretion of small lipoprotein particles in apobec-1−/− mice is regulated by the LDL receptor
F Nassir, Y Xie, BW Patterson, J Luo… - Journal of lipid …, 2004 - ASBMB
Recent studies have examined the role of the LDL receptor (LDLR) in regulating murine
hepatic lipoprotein production and apolipoprotein B (apoB) secretion, with divergent
conclusions from in vivo versus in vitro approaches. We have re-examined this question,
both in vivo and in vitro, using apobec-1−/− mice to model the pattern of human hepatic
apoB-100 secretion. Hepatic triglyceride production in vivo (using Triton WR-1339) was
unchanged in wild-type (WT) C57BL/6, apobec-1−/−, ldlr−/−, and [apobec-1−/−, ldlr−/−] mice …
hepatic lipoprotein production and apolipoprotein B (apoB) secretion, with divergent
conclusions from in vivo versus in vitro approaches. We have re-examined this question,
both in vivo and in vitro, using apobec-1−/− mice to model the pattern of human hepatic
apoB-100 secretion. Hepatic triglyceride production in vivo (using Triton WR-1339) was
unchanged in wild-type (WT) C57BL/6, apobec-1−/−, ldlr−/−, and [apobec-1−/−, ldlr−/−] mice …
