Disruption of amyloid precursor protein ubiquitination selectively increases amyloid β (Aβ) 40 levels via presenilin 2-mediated cleavage
RL Williamson, K Laulagnier, AM Miranda… - Journal of Biological …, 2017 - jbc.org
Amyloid plaques, a neuropathological hallmark of Alzheimer's disease, are largely
composed of amyloid β (Aβ) peptide, derived from cleavage of amyloid precursor protein
(APP) by β-and γ-secretases. The endosome is increasingly recognized as an important
crossroad for APP and these secretases, with major implications for APP processing and
amyloidogenesis. Among various post-translational modifications affecting APP
accumulation, ubiquitination of cytodomain lysines may represent a key signal controlling …
composed of amyloid β (Aβ) peptide, derived from cleavage of amyloid precursor protein
(APP) by β-and γ-secretases. The endosome is increasingly recognized as an important
crossroad for APP and these secretases, with major implications for APP processing and
amyloidogenesis. Among various post-translational modifications affecting APP
accumulation, ubiquitination of cytodomain lysines may represent a key signal controlling …