Induced mutant mice expressing lipoprotein lipase exclusively in muscle have subnormal triglycerides yet reduced high density lipoprotein cholesterol levels in …
S Levak-Frank, PH Weinstock, T Hayek… - Journal of Biological …, 1997 - jbc.org
To determine the contribution of muscle lipoprotein lipase (LPL) to lipoprotein metabolism,
induced mutant mice were generated that express human LPL exclusively in muscle. By
cross-breeding heterozygous LPL knockout mice with transgenic mice expressing human
LPL only in muscle, animals were obtained that express human LPL primarily in skeletal
muscle on either the null (L0-MCK) or normal (L2-MCK) LPL backgrounds, and these were
compared with control littermates (L2). Fed and fasted post-heparin plasma (PHP) LPL …
induced mutant mice were generated that express human LPL exclusively in muscle. By
cross-breeding heterozygous LPL knockout mice with transgenic mice expressing human
LPL only in muscle, animals were obtained that express human LPL primarily in skeletal
muscle on either the null (L0-MCK) or normal (L2-MCK) LPL backgrounds, and these were
compared with control littermates (L2). Fed and fasted post-heparin plasma (PHP) LPL …