CpG motifs in bacterial DNA and their immune effects
AM Krieg - Annual review of immunology, 2002 - annualreviews.org
Unmethylated CpG motifs are prevalent in bacterial but not vertebrate genomic DNAs.
Oligodeoxynucleotides (ODN) containing CpG motifs activate host defense mechanisms
leading to innate and acquired immune responses. The recognition of CpG motifs requires
Toll-like receptor (TLR) 9, which triggers alterations in cellular redox balance and the
induction of cell signaling pathways including the mitogen activated protein kinases
(MAPKs) and NFκB. Cells that express TLR-9, which include plasmacytoid dendritic cells …
Oligodeoxynucleotides (ODN) containing CpG motifs activate host defense mechanisms
leading to innate and acquired immune responses. The recognition of CpG motifs requires
Toll-like receptor (TLR) 9, which triggers alterations in cellular redox balance and the
induction of cell signaling pathways including the mitogen activated protein kinases
(MAPKs) and NFκB. Cells that express TLR-9, which include plasmacytoid dendritic cells …
