Roles for the MH2 domain of Smad7 in the specific inhibition of transforming growth factor-β superfamily signaling
T Mochizuki, H Miyazaki, T Hara, T Furuya… - Journal of Biological …, 2004 - jbc.org
Signals by cytokines of the transforming growth factor-β (TGF-β) superfamily are negatively
regulated by inhibitory Smads (I-Smads). Smad7 inhibits signaling by both TGF-β and bone
morphogenetic proteins (BMPs), whereas Smad6 inhibits TGF-β signals less effectively. I-
Smads have amino-terminal N domains and carboxyl-terminal Mad homology 2 (MH2)
domains. The N domains are essential for specific inhibition of TGF-β signaling by Smad7,
whereas the MH2 domains of I-Smads are involved in the inhibition of TGF-β superfamily …
regulated by inhibitory Smads (I-Smads). Smad7 inhibits signaling by both TGF-β and bone
morphogenetic proteins (BMPs), whereas Smad6 inhibits TGF-β signals less effectively. I-
Smads have amino-terminal N domains and carboxyl-terminal Mad homology 2 (MH2)
domains. The N domains are essential for specific inhibition of TGF-β signaling by Smad7,
whereas the MH2 domains of I-Smads are involved in the inhibition of TGF-β superfamily …