▪ Abstract Many metazoan cells inhabit mechanically stressful environments and,
consequently, their plasma membranes are frequently disrupted. Survival requires that the
cell rapidly repair or reseal the disruption. Rapid resealing is an active and complex
structural modification that employs endomembrane as its primary building block, and
cytoskeletal and membrane fusion proteins as its catalysts. Endomembrane is delivered to
the damaged plasma membrane through exocytosis, a ubiquitous Ca2+-triggered response …