Molecular mechanisms governing reading frame choice of immunoglobulin diversity genes
The key elements of antigen-binding immunoglobulin (lg) variable regions are primarily
encoded by diversity (DH) genes. Although DH genes can be used in all three reading
frames, the majority of peripheral lg molecules carry a DH element in a single reading frame.
Here, Frank Raaphorst, C. Raman, Barry Nall and Judy Teale discuss the particular
demands imposed by the structure of the antigen-binding site, which determine the choice of
reading frame.
encoded by diversity (DH) genes. Although DH genes can be used in all three reading
frames, the majority of peripheral lg molecules carry a DH element in a single reading frame.
Here, Frank Raaphorst, C. Raman, Barry Nall and Judy Teale discuss the particular
demands imposed by the structure of the antigen-binding site, which determine the choice of
reading frame.
Abstract
The key elements of antigen-binding immunoglobulin (lg) variable regions are primarily encoded by diversity (DH) genes. Although DH genes can be used in all three reading frames, the majority of peripheral lg molecules carry a DH element in a single reading frame. Here, Frank Raaphorst, C. Raman, Barry Nall and Judy Teale discuss the particular demands imposed by the structure of the antigen-binding site, which determine the choice of reading frame.
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