Shedding of syndecan-1 by stromal fibroblasts stimulates human breast cancer cell proliferation via FGF2 activation
G Su, SA Blaine, D Qiao, A Friedl - Journal of Biological Chemistry, 2007 - jbc.org
The cell surface heparan sulfate proteoglycan syndecan-1 is induced in stromal fibroblasts
of breast carcinomas and participates in a reciprocal feedback loop, which stimulates
carcinoma cell growth in vitro and in vivo. To define the molecular mechanism of carcinoma
growth stimulation, a three-dimensional co-culture model was developed that combines
T47D breast carcinoma cells with immortalized human mammary fibroblasts in collagen
gels. By silencing endogenous syndecan-1 induction with short interfering RNA and …
of breast carcinomas and participates in a reciprocal feedback loop, which stimulates
carcinoma cell growth in vitro and in vivo. To define the molecular mechanism of carcinoma
growth stimulation, a three-dimensional co-culture model was developed that combines
T47D breast carcinoma cells with immortalized human mammary fibroblasts in collagen
gels. By silencing endogenous syndecan-1 induction with short interfering RNA and …