[HTML][HTML] The wrinkling of time: Aging, inflammation, oxidative stress, and the circadian clock in neurodegeneration
BV Lananna, ES Musiek - Neurobiology of disease, 2020 - Elsevier
Neurobiology of disease, 2020•Elsevier
A substantial body of research now implicates the circadian clock in the regulation of an
array of diverse biological processes including glial function, metabolism, peripheral
immune responses, and redox homeostasis. Sleep abnormalities and other forms of
circadian disruption are common symptoms of aging and neurodegeneration. Circadian
clock disruption may also influence the aging processes and the pathogenesis of
neurodegenerative diseases. The specific mechanisms governing the interaction between …
array of diverse biological processes including glial function, metabolism, peripheral
immune responses, and redox homeostasis. Sleep abnormalities and other forms of
circadian disruption are common symptoms of aging and neurodegeneration. Circadian
clock disruption may also influence the aging processes and the pathogenesis of
neurodegenerative diseases. The specific mechanisms governing the interaction between …
Abstract
A substantial body of research now implicates the circadian clock in the regulation of an array of diverse biological processes including glial function, metabolism, peripheral immune responses, and redox homeostasis. Sleep abnormalities and other forms of circadian disruption are common symptoms of aging and neurodegeneration. Circadian clock disruption may also influence the aging processes and the pathogenesis of neurodegenerative diseases. The specific mechanisms governing the interaction between circadian systems, aging, and the immune system are still being uncovered. Here, we review the evidence supporting a bidirectional relationship between aging and the circadian system. Further, we explore the hypothesis that age-related circadian deterioration may exacerbate multiple pathogenic processes, priming the brain for neurodegeneration.
Elsevier