Diverse roles for the LDL receptor family
DK Strickland, SL Gonias, WS Argraves - Trends in Endocrinology & …, 2002 - cell.com
DK Strickland, SL Gonias, WS Argraves
Trends in Endocrinology & Metabolism, 2002•cell.comThe low-density lipoprotein (LDL) receptor family consists of several related scavenger
receptors that not only function as important cargo transporters, but also inform the cell of
changes in its environment by mediating signaling responses. The LDL receptor was the first
family member to be characterized and its function seems to be restricted to lipoprotein
metabolism. By contrast, lipoprotein metabolism does not appear to be the exclusive
function of the other characterized LDL receptor family members. It is now apparent that …
receptors that not only function as important cargo transporters, but also inform the cell of
changes in its environment by mediating signaling responses. The LDL receptor was the first
family member to be characterized and its function seems to be restricted to lipoprotein
metabolism. By contrast, lipoprotein metabolism does not appear to be the exclusive
function of the other characterized LDL receptor family members. It is now apparent that …
Abstract
The low-density lipoprotein (LDL) receptor family consists of several related scavenger receptors that not only function as important cargo transporters, but also inform the cell of changes in its environment by mediating signaling responses. The LDL receptor was the first family member to be characterized and its function seems to be restricted to lipoprotein metabolism. By contrast, lipoprotein metabolism does not appear to be the exclusive function of the other characterized LDL receptor family members. It is now apparent that cargo transport by members of the LDL receptor family is closely associated with regulation of cellular physiology and cellular signaling events. Here, we focus on the diverse biological activities of certain members of this family.
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