Membrane prostaglandin E synthase-1: a novel therapeutic target
B Samuelsson, R Morgenstern, PJ Jakobsson - Pharmacological reviews, 2007 - Elsevier
Abstract Prostaglandin E 2 (PGE 2) is the most abundant prostaglandin in the human body. It
has a large number of biological actions that it exerts via four types of receptors, EP1–4.
PGE 2 is formed from arachidonic acid by cyclooxygenase (COX-1 and COX-2)-catalyzed
formation of prostaglandin H 2 (PGH 2) and further transformation by PGE synthases. The
isomerization of the endoperoxide PGH 2 to PGE 2 is catalyzed by three different PGE
synthases, viz. cytosolic PGE synthase (cPGES) and two membrane-bound PGE synthases …
has a large number of biological actions that it exerts via four types of receptors, EP1–4.
PGE 2 is formed from arachidonic acid by cyclooxygenase (COX-1 and COX-2)-catalyzed
formation of prostaglandin H 2 (PGH 2) and further transformation by PGE synthases. The
isomerization of the endoperoxide PGH 2 to PGE 2 is catalyzed by three different PGE
synthases, viz. cytosolic PGE synthase (cPGES) and two membrane-bound PGE synthases …