Effect of hydroxyurea on mortality and morbidity in adult sickle cell anemia: risks and benefits up to 9 years of treatment
MH Steinberg, F Barton, O Castro, CH Pegelow… - Jama, 2003 - jamanetwork.com
Context Hydroxyurea increases levels of fetal hemoglobin (HbF) and decreases morbidity
from vaso-occlusive complications in patients with sickle cell anemia (SCA). High HbF levels
reduce morbidity and mortality. Objective To determine whether hydroxyurea attenuates
mortality in patients with SCA. Design Long-term observational follow-up study of mortality in
patients with SCA who originally participated in the randomized, double-blind, placebo-
controlled Multicenter Study of Hydroxyurea in Sickle Cell Anemia (MSH), conducted in …
from vaso-occlusive complications in patients with sickle cell anemia (SCA). High HbF levels
reduce morbidity and mortality. Objective To determine whether hydroxyurea attenuates
mortality in patients with SCA. Design Long-term observational follow-up study of mortality in
patients with SCA who originally participated in the randomized, double-blind, placebo-
controlled Multicenter Study of Hydroxyurea in Sickle Cell Anemia (MSH), conducted in …