Stress and drug abuse-related disorders: The promising therapeutic value of neurosteroids focus on pregnenolone-progesterone-allopregnanolone pathway
G Tomaselli, M Vallée - Frontiers in Neuroendocrinology, 2019 - Elsevier
The pregnenolone-progesterone-allopregnanolone pathway is receiving increasing
attention in research on the role of neurosteroids in pathophysiology, particularly in stress-
related and drug use disorders. These disorders involve an allostatic change that may result
from deficiencies in allostasis or adaptive responses, and may be downregulated by
adjustments in neurotransmission by neurosteroids. The following is an overview of findings
that assess how pregnenolone and/or allopregnanolone concentrations are altered in …
attention in research on the role of neurosteroids in pathophysiology, particularly in stress-
related and drug use disorders. These disorders involve an allostatic change that may result
from deficiencies in allostasis or adaptive responses, and may be downregulated by
adjustments in neurotransmission by neurosteroids. The following is an overview of findings
that assess how pregnenolone and/or allopregnanolone concentrations are altered in …