Neural plate patterning: upstream and downstream of the isthmic organizer

W Wurst, L Bally-Cuif - Nature Reviews Neuroscience, 2001 - nature.com
Nature Reviews Neuroscience, 2001nature.com
Two organizing centres operate at long-range distances within the anterior neural plate to
pattern the forebrain, midbrain and hindbrain. Important progress has been made in
understanding the formation and function of one of these organizing centres, the isthmic
organizer, which controls the development of the midbrain and anterior hindbrain. Here we
review our current knowledge on the identity, localization and maintenance of the isthmic
organizer, as well as on the molecular cascades that underlie the activity of this organizing …
Abstract
Two organizing centres operate at long-range distances within the anterior neural plate to pattern the forebrain, midbrain and hindbrain. Important progress has been made in understanding the formation and function of one of these organizing centres, the isthmic organizer, which controls the development of the midbrain and anterior hindbrain. Here we review our current knowledge on the identity, localization and maintenance of the isthmic organizer, as well as on the molecular cascades that underlie the activity of this organizing centre.
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