Status of prophylactic and therapeutic genital herpes vaccines
S Awasthi, HM Friedman - Current opinion in virology, 2014 - Elsevier
Highlights•Provide rationale for the need of a genital herpes vaccine.•Define goals of
therapeutic or prophylactic vaccines.•Review animal models, approaches, strengths and
weaknesses of clinical trials.•Discuss lesson learned from past trials, new strategies and
pipeline.A half billion people have genital herpes infections worldwide. Approximately one-
fifth of American women between ages 14 and 49 are HSV-2 seropositive. The development
of an effective genital herpes vaccine is a global health necessity based on the mental …
therapeutic or prophylactic vaccines.•Review animal models, approaches, strengths and
weaknesses of clinical trials.•Discuss lesson learned from past trials, new strategies and
pipeline.A half billion people have genital herpes infections worldwide. Approximately one-
fifth of American women between ages 14 and 49 are HSV-2 seropositive. The development
of an effective genital herpes vaccine is a global health necessity based on the mental …