2. Discussion

The majority COVID-19 patients present with respiratory symptoms and fever. Although rare, neurologic sequelae of COVID-19 have been reported, including syncope (Tapé et al., 2013), Guillain-Barré syndrome (Toscano et al., 2020), polyneuropathy (Gutiérrez-Ortiz et al., 2020), and stroke (Oxley et al., 2020, Li et al., 2020). We describe a case of SARS-CoV-2 infection that was entirely confined to the central nervous system, with no involvement of other organ systems. Given the patient’s clinical presentation and positive PCR testing for SARS-CoV-2 in the CSF, we propose that this case is most consistent with SARS-CoV-2 encephalitis. To our knowledge, this presentation of COVID-19 has not yet been reported and is important to consider as an atypical manifestation of the viral infection. Further, we demonstrate that RT-PCR of SARS-CoV-2 in the CSF can be considered as a detection modality for cases of COVID-19 affecting the central nervous system.