Distinct gradients of various neurotransmitter markers in caudate nucleus and putamen of the human brain
H Hörtnagl, C Pifl, E Hörtnagl, A Reiner… - Journal of …, 2020 - Wiley Online Library
The caudate nucleus (CN) and the putamen (PUT) as parts of the human striatum are
distinguished by a marked heterogeneity in functional, anatomical, and neurochemical
patterns. Our study aimed to document in detail the regional diversity in the distribution of
dopamine (DA), serotonin, γ‐aminobuturic acid, and choline acetyltransferase within the CN
and PUT. For this purpose we dissected the CN as well as the PUT of 12 post‐mortem
brains of human subjects with no evidence of neurological and psychiatric disorders (38–81 …
distinguished by a marked heterogeneity in functional, anatomical, and neurochemical
patterns. Our study aimed to document in detail the regional diversity in the distribution of
dopamine (DA), serotonin, γ‐aminobuturic acid, and choline acetyltransferase within the CN
and PUT. For this purpose we dissected the CN as well as the PUT of 12 post‐mortem
brains of human subjects with no evidence of neurological and psychiatric disorders (38–81 …
Old neurochemical markers, new functional directions? An Editorial for 'Distinct gradients of various neurotransmitter markers in caudate nucleus and putamen of the …
P De Deurwaerdere, S Gaetani… - Journal of …, 2020 - Wiley Online Library
The dorsal striatum coordinates input‐output processing of numerous functions including
those related to motor activity, motivation, and learning. Considerable anatomical and
biochemical heterogeneity across striatal subregions has long been known to result in
distinct functional outcomes, and for imbalances in these pathways to contribute to many
complex disorders. Here we highlight the study of Hörtnagl et al.(2019) who utilize precision
dissection of human caudate nucleus and putamen for detailed measurement of major …
those related to motor activity, motivation, and learning. Considerable anatomical and
biochemical heterogeneity across striatal subregions has long been known to result in
distinct functional outcomes, and for imbalances in these pathways to contribute to many
complex disorders. Here we highlight the study of Hörtnagl et al.(2019) who utilize precision
dissection of human caudate nucleus and putamen for detailed measurement of major …
