Red cell selectivity in malaria: a study of multiple-infected erythrocytes
JA Simpson, K Silamut, K Chotivanich… - Transactions of the …, 1999 - Elsevier
To characterize red cell susceptibility to invasion in malaria, a selectivity index (SI) was
calculated as the ratio of observed number of multiple-infected red cells to that expected
from a random process (Poisson distribution). In patients with falciparum malaria (n= 100) SI
decreased with increasing parasitaemia (P< 0· 001), and correlated inversely with plasma
lactate concentrations, chosen prospectively as a measure of disease severity (r=− 0· 36, P<
0· 001). For parasitaemias< 5%, the SI was lower in patients with severe malaria (geometric …
calculated as the ratio of observed number of multiple-infected red cells to that expected
from a random process (Poisson distribution). In patients with falciparum malaria (n= 100) SI
decreased with increasing parasitaemia (P< 0· 001), and correlated inversely with plasma
lactate concentrations, chosen prospectively as a measure of disease severity (r=− 0· 36, P<
0· 001). For parasitaemias< 5%, the SI was lower in patients with severe malaria (geometric …