Identification and characterization of a ligand-regulated nuclear export signal in androgen receptor
AJ Saporita, Q Zhang, N Navai, Z Dincer, J Hahn… - Journal of Biological …, 2003 - jbc.org
Androgen receptor (AR) belongs to the steroid receptor superfamily that regulates gene
expression in a ligand-dependent fashion. AR is localized to the cytoplasm in the absence of
androgen and translocates into the nuclei to activate gene expression in the presence of
ligand. Regulation of AR nuclear import and export represents an essential step in androgen
action. A nuclear localization signal (NLS) has been identified in the DNA-binding domain
and hinge region of AR and other steroid receptors. Studies on nuclear export of AR …
expression in a ligand-dependent fashion. AR is localized to the cytoplasm in the absence of
androgen and translocates into the nuclei to activate gene expression in the presence of
ligand. Regulation of AR nuclear import and export represents an essential step in androgen
action. A nuclear localization signal (NLS) has been identified in the DNA-binding domain
and hinge region of AR and other steroid receptors. Studies on nuclear export of AR …