Inhibition of FcεRI-dependent mediator release and calcium flux from human mast cells by sialic acid–binding immunoglobulin-like lectin 8 engagement
H Yokoi, OH Choi, W Hubbard, HS Lee… - Journal of allergy and …, 2008 - Elsevier
BACKGROUND: Sialic acid–binding immunoglobulin-like lectins (Siglecs) are a family of
glycan-binding inhibitory receptors, and among them, Siglec-8 is selectively expressed on
human eosinophils, basophils, and mast cells. On eosinophils, Siglec-8 engagement
induces apoptosis, but its function on mast cells is unknown. OBJECTIVE: We sought to
study the effect of Siglec-8 engagement on human mast cell survival and mediator release
responses. METHODS: Human mast cells were generated from CD34+ precursors …
glycan-binding inhibitory receptors, and among them, Siglec-8 is selectively expressed on
human eosinophils, basophils, and mast cells. On eosinophils, Siglec-8 engagement
induces apoptosis, but its function on mast cells is unknown. OBJECTIVE: We sought to
study the effect of Siglec-8 engagement on human mast cell survival and mediator release
responses. METHODS: Human mast cells were generated from CD34+ precursors …