The clinical and pathologic features of eosinophilic esophagitis (EE) include extensive
tissue remodeling. Increasing evidence supports a key role for the eosinophil in multiple
aspects of the esophageal remodeling and fibrosis seen in this allergic disease. This article
reviews the clinical implications of esophageal remodeling and fibrosis in EE and discusses
the possible pathogenic mechanisms inducing and regulating these responses. The focus is
specifically on eosinophil and cytokine interactions with the esophageal epithelium, vascular …