Sildenafil: a review of its use in erectile dysfunction
HD Langtry, A Markham - Drugs, 1999 - Springer
HD Langtry, A Markham
Drugs, 1999•SpringerSildenafil is an oral therapy for erectile dysfunction of a broad range of causes. By
selectively inhibiting phosphodiesterase type 5, it allows corpus cavernosum smooth muscle
to relax, potentiating erections during sexual stimulation. Blood pressure is reduced
transiently by sildenafil, but more marked hypotension may occur during concurrent
administration of sildenafil and organic nitrates; this combination is contraindicated.
selectively inhibiting phosphodiesterase type 5, it allows corpus cavernosum smooth muscle
to relax, potentiating erections during sexual stimulation. Blood pressure is reduced
transiently by sildenafil, but more marked hypotension may occur during concurrent
administration of sildenafil and organic nitrates; this combination is contraindicated.
Abstract
Sildenafil is an oral therapy for erectile dysfunction of a broad range of causes. By selectively inhibiting phosphodiesterase type 5, it allows corpus cavernosum smooth muscle to relax, potentiating erections during sexual stimulation. Blood pressure is reduced transiently by sildenafil, but more marked hypotension may occur during concurrent administration of sildenafil and organic nitrates; this combination is contraindicated.
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