NFκB promotes inflammation, coagulation, and fibrosis in the aging glomerulus
JE Wiggins, SR Patel, KA Shedden… - Journal of the …, 2010 - journals.lww.com
The peak prevalence of ESRD from glomerulosclerosis occurs at 70 to 79 years. To
understand why old glomeruli are prone to failure, we analyzed the Fischer 344 rat model of
aging under ad libitum-fed (rapid aging) and calorie-restricted (slowed aging) conditions. All
glomerular cells contained genes whose expression changed “linearly” during adult life from
2 to 24 months: mesangial cells (eg, MMP9), endothelial cells (eg, ICAM and VCAM),
parietal epithelial cells (eg, ceruloplasmin), and podocytes (eg, nephrin and …
understand why old glomeruli are prone to failure, we analyzed the Fischer 344 rat model of
aging under ad libitum-fed (rapid aging) and calorie-restricted (slowed aging) conditions. All
glomerular cells contained genes whose expression changed “linearly” during adult life from
2 to 24 months: mesangial cells (eg, MMP9), endothelial cells (eg, ICAM and VCAM),
parietal epithelial cells (eg, ceruloplasmin), and podocytes (eg, nephrin and …