CD39 limits P2X7 receptor inflammatory signaling and attenuates sepsis-induced liver injury
LEB Savio, P de Andrade Mello, VR Figliuolo… - Journal of …, 2017 - Elsevier
Background & Aims The severity of sepsis can be linked to excessive inflammatory
responses resulting in hepatic injury. P2X7 receptor activation by extracellular ATP (eATP)
exacerbates inflammation by augmenting cytokine production; while CD39 (ENTPD1)
scavenges eATP to generate adenosine, thereby limiting P2X7 activation and resulting in A
2A receptor stimulation. We aim to determine how the functional interaction of P2X7 receptor
and CD39 control the macrophage response, and consequently impact on sepsis and liver …
responses resulting in hepatic injury. P2X7 receptor activation by extracellular ATP (eATP)
exacerbates inflammation by augmenting cytokine production; while CD39 (ENTPD1)
scavenges eATP to generate adenosine, thereby limiting P2X7 activation and resulting in A
2A receptor stimulation. We aim to determine how the functional interaction of P2X7 receptor
and CD39 control the macrophage response, and consequently impact on sepsis and liver …