Background & Aims p38 mitogen-activated protein kinases are important inflammatory
factors. p38α alteration has been implicated in both human and mouse inflammatory
disease models. Therefore, we aimed to characterize the cell type-specific role of p38α in
non-alcoholic steatohepatitis (NASH). Methods Human liver tissues were obtained from 27
patients with non-alcoholic fatty liver disease (NAFLD) and 20 control individuals. NASH
was established and compared between hepatocyte-specific p38α knockout (p38α ΔHep) …