After a century of controversy, the notion that the immune system regulates cancer
development is experiencing a new resurgence. An overwhelming amount of data from
animal models—together with compelling data from human patients—indicate that a
functional cancer immunosurveillance process indeed exists that acts as an extrinsic tumor
suppressor. However, it has also become clear that the immune system can facilitate tumor
progression, at least in part, by sculpting the immunogenic phenotype of tumors as they …