Prevention of primary graft dysfunction in lung transplantation by N-acetylcysteine after prolonged cold ischemia
I Inci, B Erne, S Arni, W Jungraithmayr, D Inci… - The Journal of heart and …, 2010 - Elsevier
BACKGROUND:: N-Acetylcysteine (NAC), a thiol-containing compound that has been used
as an anti-oxidant, may also lead to an increased glutathione synthesis. This study assessed
the protective effect of NAC on primary graft dysfunction after lung transplantation.
METHODS:: Porcine single left-lung transplantation was performed in 2 experimental groups
after 24 hours of cold storage. Donor and recipient animals were treated with intravenous
injection of 150 mg/kg NAC 60 minutes before harvest and reperfusion, followed by 12.5 …
as an anti-oxidant, may also lead to an increased glutathione synthesis. This study assessed
the protective effect of NAC on primary graft dysfunction after lung transplantation.
METHODS:: Porcine single left-lung transplantation was performed in 2 experimental groups
after 24 hours of cold storage. Donor and recipient animals were treated with intravenous
injection of 150 mg/kg NAC 60 minutes before harvest and reperfusion, followed by 12.5 …