Obesity is a common disorder and a known risk factor for thrombotic complications.
Development of obesity is associated with extensive modifications in adipose tissue
involving adipogenesis, angiogenesis and extracellular matrix proteolysis. The fibrinolytic
(plasminogen/plasmin) system plays an important role in these processes. Studies using a
nutritionally induced obesity model in transgenic mice support a role of the fibrinolytic
system in adipogenesis and obesity. Studies using venous or arterial thrombosis models in …