Visceral fat as a main determinant of plasminogen activator inhibitor 1 level in women
B Janand-Delenne, C Chagnaud, D Raccah… - International journal of …, 1998 - nature.com
B Janand-Delenne, C Chagnaud, D Raccah, MC Alessi, I Juhan-Vague, P Vague
International journal of obesity, 1998•nature.comOBJECTIVE: To substantiate in a premenopausal population of women, the link between
visceral adipose tissue and circulating plasminogen activator inhibitor 1 (PAI-1) levels.
DESIGN: Study of correlations between anthropometric parameters and PAI-1 and
evaluation of the changes induced by weight loss. SUBJECTS: Forty-two healthy pre-
menopausal women (aged 18–51 y, with a wide range of body mass index (BMI, 21–48.8
kg/m 2). Thirteen women were evaluated after weight loss (6.6±3.3 kg). MEASUREMENTS …
visceral adipose tissue and circulating plasminogen activator inhibitor 1 (PAI-1) levels.
DESIGN: Study of correlations between anthropometric parameters and PAI-1 and
evaluation of the changes induced by weight loss. SUBJECTS: Forty-two healthy pre-
menopausal women (aged 18–51 y, with a wide range of body mass index (BMI, 21–48.8
kg/m 2). Thirteen women were evaluated after weight loss (6.6±3.3 kg). MEASUREMENTS …
Abstract
OBJECTIVE: To substantiate in a premenopausal population of women, the link between visceral adipose tissue and circulating plasminogen activator inhibitor 1 (PAI-1) levels.
DESIGN: Study of correlations between anthropometric parameters and PAI-1 and evaluation of the changes induced by weight loss.
SUBJECTS: Forty-two healthy pre-menopausal women (aged 18–51 y, with a wide range of body mass index (BMI, 21–48.8 kg/m 2). Thirteen women were evaluated after weight loss (6.6±3.3 kg).
MEASUREMENTS: BMI, waist and hip circumferences. Total, subcutaneous and visceral adipose tissue areas at the L3–L4 level by computed tomography. Insulin, cholesterol, triglyceride, HDL cholesterol, PAI-1 activity, PAI-1 antigen and tissue plasminogen activator (tPA) antigen.
RESULTS: PAI-1 activity, PAI antigen and tPA antigen were positively correlated with visceral adipose tissue, but not with subcutaneous adipose tissue. This correlation was independent of insulin or triglyceride levels. The amount of visceral adipose tissue explained 28% of the PAI-1 activity variance.
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