[PDF][PDF] A phase separation model for transcriptional control
Cell, 2017•cell.com
Phase-separated multi-molecular assemblies provide a general regulatory mechanism to
compartmentalize biochemical reactions within cells. We propose that a phase separation
model explains established and recently described features of transcriptional control. These
features include the formation of super-enhancers, the sensitivity of super-enhancers to
perturbation, the transcriptional bursting patterns of enhancers, and the ability of an
enhancer to produce simultaneous activation at multiple genes. This model provides a …
compartmentalize biochemical reactions within cells. We propose that a phase separation
model explains established and recently described features of transcriptional control. These
features include the formation of super-enhancers, the sensitivity of super-enhancers to
perturbation, the transcriptional bursting patterns of enhancers, and the ability of an
enhancer to produce simultaneous activation at multiple genes. This model provides a …
Phase-separated multi-molecular assemblies provide a general regulatory mechanism to compartmentalize biochemical reactions within cells. We propose that a phase separation model explains established and recently described features of transcriptional control. These features include the formation of super-enhancers, the sensitivity of super-enhancers to perturbation, the transcriptional bursting patterns of enhancers, and the ability of an enhancer to produce simultaneous activation at multiple genes. This model provides a conceptual framework to further explore principles of gene control in mammals.
cell.com