[HTML][HTML] An IL-1 family member requires caspase-1 processing and signals through the ST2 receptor
CA Dinarello - Immunity, 2005 - cell.com
CA Dinarello
Immunity, 2005•cell.comActivation of ST2, an orphan member of the IL-1 receptor family for 16 years, drives T helper
type 2 (TH 2) responses. The cytokine IL-33 is the specific ligand for ST2. IL-33 recapitulates
much of the existing data that ST2 promotes TH 2-type responses. The caspase-1
processing of precursor IL-33 provides a therapeutic target to control allergic diseases.
type 2 (TH 2) responses. The cytokine IL-33 is the specific ligand for ST2. IL-33 recapitulates
much of the existing data that ST2 promotes TH 2-type responses. The caspase-1
processing of precursor IL-33 provides a therapeutic target to control allergic diseases.
Activation of ST2, an orphan member of the IL-1 receptor family for 16 years, drives T helper type 2 (TH2) responses. The cytokine IL-33 is the specific ligand for ST2. IL-33 recapitulates much of the existing data that ST2 promotes TH2-type responses. The caspase-1 processing of precursor IL-33 provides a therapeutic target to control allergic diseases.
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