Allergen-specific immunotherapy modulates the balance of circulating Tfh and Tfr cells
V Schulten, V Tripple, G Seumois, Y Qian… - Journal of Allergy and …, 2018 - jacionline.org
LETTERS TO THE EDITOR 775 frequently coexpressed on a single-cell level, whereas
Granzyme A is expressed by a different subpopulation within the CXCR5lo cells. Given the
upregulation of Foxp3 and Helios in CXCR5lo cells, we analyzed the median fluorescence
intensity of CXCR5 in classical Tfh (CXCR5 1 FOXP3 2 Helios 2) versus Tfr (CXCR5 1
FOXP3 1 Helios 1) cells (Fig 2, C). A pronounced difference in CXCR5 expression (P>.
0001) was observed in the Tfr subset compared with Tfh cells, indicating that Tfr cells fall …
Granzyme A is expressed by a different subpopulation within the CXCR5lo cells. Given the
upregulation of Foxp3 and Helios in CXCR5lo cells, we analyzed the median fluorescence
intensity of CXCR5 in classical Tfh (CXCR5 1 FOXP3 2 Helios 2) versus Tfr (CXCR5 1
FOXP3 1 Helios 1) cells (Fig 2, C). A pronounced difference in CXCR5 expression (P>.
0001) was observed in the Tfr subset compared with Tfh cells, indicating that Tfr cells fall …
