Ebna1
L Frappier - Epstein Barr Virus Volume 2: One Herpes Virus: Many …, 2015 - Springer
Epstein Barr Virus Volume 2: One Herpes Virus: Many Diseases, 2015•Springer
Epstein–Barr nuclear antigen 1 (EBNA1) plays multiple important roles in EBV latent
infection and has also been shown to impact EBV lytic infection. EBNA1 is required for the
stable persistence of the EBV genomes in latent infection and activates the expression of
other EBV latency genes through interactions with specific DNA sequences in the viral
episomes. EBNA1 also interacts with several cellular proteins to modulate the activities of
multiple cellular pathways important for viral persistence and cell survival. These cellular …
infection and has also been shown to impact EBV lytic infection. EBNA1 is required for the
stable persistence of the EBV genomes in latent infection and activates the expression of
other EBV latency genes through interactions with specific DNA sequences in the viral
episomes. EBNA1 also interacts with several cellular proteins to modulate the activities of
multiple cellular pathways important for viral persistence and cell survival. These cellular …
Abstract
Epstein–Barr nuclear antigen 1 (EBNA1) plays multiple important roles in EBV latent infection and has also been shown to impact EBV lytic infection. EBNA1 is required for the stable persistence of the EBV genomes in latent infection and activates the expression of other EBV latency genes through interactions with specific DNA sequences in the viral episomes. EBNA1 also interacts with several cellular proteins to modulate the activities of multiple cellular pathways important for viral persistence and cell survival. These cellular effects are also implicated in oncogenesis, suggesting a direct role of EBNA1 in the development of EBV-associated tumors.
Springer
