The miRNAs of herpes simplex virus (HSV)
L Sun, Q Li - Virologica Sinica, 2012 - Springer
L Sun, Q Li
Virologica Sinica, 2012•SpringerHerpes simplex virus (HSV) is a group of common human pathogens with two serotypes
HSV-1 and HSV-2. The prevalence of HSV is worldwide. It primarily infects humans through
epithelial cells, when it introduces a latent infection into the nervous system. During viral
latency, only a region known as the latency-associated transcript (LAT) is expressed. The
discovery of HSV miRNAs helps to draw a larger picture of the infection and pathogenesis of
the virus. This review summarizes miRNAs found in HSV-1 and HSV-2 so far. The functional …
HSV-1 and HSV-2. The prevalence of HSV is worldwide. It primarily infects humans through
epithelial cells, when it introduces a latent infection into the nervous system. During viral
latency, only a region known as the latency-associated transcript (LAT) is expressed. The
discovery of HSV miRNAs helps to draw a larger picture of the infection and pathogenesis of
the virus. This review summarizes miRNAs found in HSV-1 and HSV-2 so far. The functional …
Abstract
Herpes simplex virus (HSV) is a group of common human pathogens with two serotypes HSV-1 and HSV-2. The prevalence of HSV is worldwide. It primarily infects humans through epithelial cells, when it introduces a latent infection into the nervous system. During viral latency, only a region known as the latency-associated transcript (LAT) is expressed. The discovery of HSV miRNAs helps to draw a larger picture of the infection and pathogenesis of the virus. This review summarizes miRNAs found in HSV-1 and HSV-2 so far. The functional studies of miRNAs in HSV to date indicate that they play a stage-specific role coordinated with viral proteins to maintain the virus life cycle.
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