Baseline intrahepatic and peripheral innate immunity are associated with hepatitis C virus clearance during direct‐acting antiviral therapy
H Alao, M Cam, C Keembiyehetty, F Zhang, E Serti… - Hepatology, 2018 - journals.lww.com
Hepatitis C virus (HCV) infection induces interferon (IFN)‐stimulated genes (ISGs) and
downstream innate immune responses. This study investigated whether baseline and on‐
treatment differences in these responses predict response versus virological breakthrough
during therapy with direct‐acting antivirals (DAAs). Thirteen HCV genotype 1b–infected
patients who had previously failed a course of pegylated IFN/ribavirin were retreated with
asunaprevir/daclatasvir for 24 weeks. After pretreatment biopsy, patients were randomized …
downstream innate immune responses. This study investigated whether baseline and on‐
treatment differences in these responses predict response versus virological breakthrough
during therapy with direct‐acting antivirals (DAAs). Thirteen HCV genotype 1b–infected
patients who had previously failed a course of pegylated IFN/ribavirin were retreated with
asunaprevir/daclatasvir for 24 weeks. After pretreatment biopsy, patients were randomized …
