[HTML][HTML] Grb2 forms an inducible protein complex with CD28 through a Src homology 3 domain-proline interaction
K Okkenhaug, R Rottapel - Journal of Biological Chemistry, 1998 - ASBMB
CD28 provides a costimulatory signal that results in optimal activation of T cells. The signal
transduction pathways necessary for CD28-mediated costimulation are presently unknown.
Engagement of CD28 leads to its tyrosine phosphorylation and subsequent binding to Src
homology 2 (SH2)-containing proteins including the p85 subunit of phosphatidylinositol 3′-
kinase (PI3K); however, the contribution of PI3K to CD28-dependent costimulation remains
controversial. Here we show that CD28 is capable of binding the Src homology 3 (SH3) …
transduction pathways necessary for CD28-mediated costimulation are presently unknown.
Engagement of CD28 leads to its tyrosine phosphorylation and subsequent binding to Src
homology 2 (SH2)-containing proteins including the p85 subunit of phosphatidylinositol 3′-
kinase (PI3K); however, the contribution of PI3K to CD28-dependent costimulation remains
controversial. Here we show that CD28 is capable of binding the Src homology 3 (SH3) …