Localization of the type 3 inositol 1, 4, 5-trisphosphate receptor in the Ca2+ wave trigger zone of pancreatic acinar cells.
MH Nathanson, MB Fallon, PJ Padfield… - Journal of Biological …, 1994 - ASBMB
Agonist-induced cytosolic Ca2+ (Ca2+ i) signals begin as apical-to-basal Ca2+ i waves in
pancreatic acinar cells and in other polarized epithelia. However, the basis of this polarized
Ca2+ i signaling pattern is unknown. Here we use immunocytochemistry to demonstrate that
the type 3 inositol trisphosphate receptor is localized to the extreme apex of pancreatic
acinar cells, the region which corresponds to the trigger zone from which Ca2+ i signals
originate in this cell type (Kasai, H., Li, YX, and Miyashita, Y.(1993) Cell 74, 669-677). We …
pancreatic acinar cells and in other polarized epithelia. However, the basis of this polarized
Ca2+ i signaling pattern is unknown. Here we use immunocytochemistry to demonstrate that
the type 3 inositol trisphosphate receptor is localized to the extreme apex of pancreatic
acinar cells, the region which corresponds to the trigger zone from which Ca2+ i signals
originate in this cell type (Kasai, H., Li, YX, and Miyashita, Y.(1993) Cell 74, 669-677). We …
