[HTML][HTML] The BAP1/ASXL2 Histone H2A Deubiquitinase Complex Regulates Cell Proliferation and Is Disrupted in Cancer*♦
S Daou, I Hammond-Martel, N Mashtalir… - Journal of Biological …, 2015 - ASBMB
The deubiquitinase (DUB) and tumor suppressor BAP1 catalyzes ubiquitin removal from
histone H2A Lys-119 and coordinates cell proliferation, but how BAP1 partners modulate its
function remains poorly understood. Here, we report that BAP1 forms two mutually exclusive
complexes with the transcriptional regulators ASXL1 and ASXL2, which are necessary for
maintaining proper protein levels of this DUB. Conversely, BAP1 is essential for maintaining
ASXL2, but not ASXL1, protein stability. Notably, cancer-associated loss of BAP1 expression …
histone H2A Lys-119 and coordinates cell proliferation, but how BAP1 partners modulate its
function remains poorly understood. Here, we report that BAP1 forms two mutually exclusive
complexes with the transcriptional regulators ASXL1 and ASXL2, which are necessary for
maintaining proper protein levels of this DUB. Conversely, BAP1 is essential for maintaining
ASXL2, but not ASXL1, protein stability. Notably, cancer-associated loss of BAP1 expression …