The triglyceride lipases of the pancreas
ME Lowe - Journal of lipid research, 2002 - ASBMB
Pancreatic triglyceride lipase (P33333344) and its protein cofactor, colipase, are required for
efficient dietary triglyceride digestion. In addition to PTL, pancreatic acinar cells synthesize
two pancreatic lipase related proteins (PLRP1 and PLRP2), which have a high degree of
sequence and structural homology with PTL. PLRP1 has no known activity. PTL and PLRP2
differ in substrate specificity, behavior in bile salts and dependence on colipase. Each
protein has a globular amino-terminal (N-terminal) domain, which contains the catalytic site …
efficient dietary triglyceride digestion. In addition to PTL, pancreatic acinar cells synthesize
two pancreatic lipase related proteins (PLRP1 and PLRP2), which have a high degree of
sequence and structural homology with PTL. PLRP1 has no known activity. PTL and PLRP2
differ in substrate specificity, behavior in bile salts and dependence on colipase. Each
protein has a globular amino-terminal (N-terminal) domain, which contains the catalytic site …
